Ranolazine and Silent Ischemia
نویسندگان
چکیده
منابع مشابه
Silent Ischemia
Myocardial ischemia can occur without overt symptoms. In fact, asymptomatic (or silent) ST-segment depression during ambulatory electrocardiogram monitoring occurs more often than symptomatic ST-segment depression in patients with coronary artery disease. Initial studies documented that silent ischemia provided independent prediction of adverse outcomes in patients with known and unknown corona...
متن کاملSilent myocardial ischemia.
Silent myocardial ischemia is increasingly recognized as a common phenomenon in a variety of people with coronary artery disease. The natural history is poorly understood, but available data suggest that silent ischemia adversely affects prognosis in all groups studied. Based on this information, we believe that efforts should be directed at detecting and aggressively treating silent ischemic e...
متن کاملNatural History of Silent Ischemia
T herapeutic decisions in patients with coronary artery disease are frequently based on the severity of chest pain despite the lack of correlation between severity of symptoms and prognosis. There are many circumstances in which objective evidence for myocardial ischemia is present but symptoms are absent. Episodes of so-called “silent myocardial ischemia” are very frequent in some patients wit...
متن کاملSilent Myocardial Ischemia and Infarction. 2nd Edition
337 all levels, especially infectious disease specialists, immunologists, clinical microbiologists , and research scientists. This volume would be particularly useful to physicians who treat patients with AIDS, and to others who desire a comprehensive, yet readable, up-to-date discussion of the research and clinical aspects of AIDS. Silent myocardial ischemia is defined as objective evidence of...
متن کاملRanolazine, an antianginal agent, markedly reduces ventricular arrhythmias induced by ischemia and ischemia-reperfusion.
We tested the effect of the antianginal agent ranolazine on ventricular arrhythmias in an ischemic model using two protocols. In protocol 1, anesthetized rats received either vehicle or ranolazine (10 mg/kg, iv bolus) and were subjected to 5 min of left coronary artery (LCA) occlusion and 5 min of reperfusion with electrocardiogram and blood pressure monitoring. In protocol 2, rats received eit...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2011
ISSN: 0735-1097
DOI: 10.1016/j.jacc.2010.11.084